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Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies
Tumor cells evade immune destruction, at least partially, by upregulating inhibitory signals to limit effector T cell activation. Programmed death 1 (PD-1) is one of the most critical co-inhibitory molecules limiting the T-cell antitumor response. PD-1 and its ligands, PD-L1 and PD-L2, are overexpre...
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| Pubblicato in: | Biochim Biophys Acta |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733614/ https://ncbi.nlm.nih.gov/pubmed/26432723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbcan.2015.09.002 |
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