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Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies

Tumor cells evade immune destruction, at least partially, by upregulating inhibitory signals to limit effector T cell activation. Programmed death 1 (PD-1) is one of the most critical co-inhibitory molecules limiting the T-cell antitumor response. PD-1 and its ligands, PD-L1 and PD-L2, are overexpre...

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Podrobná bibliografie
Vydáno v:Biochim Biophys Acta
Hlavní autoři: Xia, Yi, Medeiros, L. Jeffrey, Young, Ken H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733614/
https://ncbi.nlm.nih.gov/pubmed/26432723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbcan.2015.09.002
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