New approach to develop ultra-high inhibitory drug using the power function of the stoichiometry of the targeted nanomachine or biocomplex

AIMS: To find methods for potent drug development by targeting to biocomplex with high copy number. METHODS: Phi29 DNA packaging motor components with different stoichiometries were used as model to assay virion assembly with Yang Hui's Triangle [Image: see text] , where Z = stoichiometry, M =...

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Vydáno v:Nanomedicine (Lond)
Hlavní autoři: Shu, Dan, Pi, Fengmei, Wang, Chi, Zhang, Peng, Guo, Peixuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Future Medicine Ltd 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733561/
https://ncbi.nlm.nih.gov/pubmed/26139124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.15.37
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