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New approach to develop ultra-high inhibitory drug using the power function of the stoichiometry of the targeted nanomachine or biocomplex
AIMS: To find methods for potent drug development by targeting to biocomplex with high copy number. METHODS: Phi29 DNA packaging motor components with different stoichiometries were used as model to assay virion assembly with Yang Hui's Triangle [Image: see text] , where Z = stoichiometry, M =...
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| 出版年: | Nanomedicine (Lond) |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Future Medicine Ltd
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733561/ https://ncbi.nlm.nih.gov/pubmed/26139124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.15.37 |
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