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Greatwall promotes cell transformation by hyperactivating AKT in human malignancies
The PP2A phosphatase is often inactivated in cancer and is considered as a tumour suppressor. A new pathway controlling PP2A activity in mitosis has been recently described. This pathway includes the Greatwall (GWL) kinase and its substrates endosulfines. At mitotic entry, GWL is activated and phosp...
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| Опубликовано в: : | eLife |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733044/ https://ncbi.nlm.nih.gov/pubmed/26613407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10115 |
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