Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

The PP2A phosphatase is often inactivated in cancer and is considered as a tumour suppressor. A new pathway controlling PP2A activity in mitosis has been recently described. This pathway includes the Greatwall (GWL) kinase and its substrates endosulfines. At mitotic entry, GWL is activated and phosp...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Vera, Jorge, Lartigue, Lydia, Vigneron, Suzanne, Gadea, Gilles, Gire, Veronique, Del Rio, Maguy, Soubeyran, Isabelle, Chibon, Frederic, Lorca, Thierry, Castro, Anna
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2015
Teme:
Cell Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733044/
https://ncbi.nlm.nih.gov/pubmed/26613407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10115
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