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Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

Here we show that the functional human ortholog of Greatwall protein kinase (Gwl) is the microtubule-associated serine/threonine kinase-like protein, MAST-L. This kinase promotes mitotic entry and maintenance in human cells by inhibiting protein phosphatase 2A (PP2A), a phosphatase that dephosphoryl...

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Detalhes bibliográficos
Main Authors: Burgess, Andrew, Vigneron, Suzanne, Brioudes, Estelle, Labbé, Jean-Claude, Lorca, Thierry, Castro, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906566/
https://ncbi.nlm.nih.gov/pubmed/20538976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914191107
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