Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system

Regulation of ubiquitin-proteasome system (UPS), which controls the turnover of short-lived proteins in eukaryotic cells, is critical in maintaining cellular proteostasis. Here we show that USP14, a major deubiquitinating enzyme that regulates the UPS, is a substrate of Akt, a serine/threonine-speci...

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Veröffentlicht in:eLife
Hauptverfasser: Xu, Daichao, Shan, Bing, Lee, Byung-Hoon, Zhu, Kezhou, Zhang, Tao, Sun, Huawang, Liu, Min, Shi, Linyu, Liang, Wei, Qian, Lihui, Xiao, Juan, Wang, Lili, Pan, Lifeng, Finley, Daniel, Yuan, Junying
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2015
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733041/
https://ncbi.nlm.nih.gov/pubmed/26523394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10510
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