Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidence from circulating and lymph nodal compartments

Whole exome sequencing and copy number aberration (CNA) analysis was performed on cells taken from peripheral blood (PB) and lymph nodes (LN) of patients with chronic lymphocytic leukaemia (CLL). Of 64 non-silent somatic mutations, 54 (84.4%) were clonal in both compartments, 3 (4.7%) were PB-specif...

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Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Del Giudice, Ilaria, Marinelli, Marilisa, Wang, Jiguang, Bonina, Silvia, Messina, Monica, Chiaretti, Sabina, Ilari, Caterina, Cafforio, Luciana, Raponi, Sara, Mauro, Francesca Romana, Di Maio, Valeria, De Propris, Maria Stefania, Nanni, Mauro, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Guarini, Anna, Rabadan, Raul, Foà, Robin
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732889/
https://ncbi.nlm.nih.gov/pubmed/26597680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.13859
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