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Disease tolerance mediated by commensal E. coli via inflammasome and IGF-1 signaling

Infections and inflammation can lead to cachexia and wasting of skeletal muscle and fat tissue by as yet poorly understood mechanisms. We observed that gut colonization of mice by a strain of Escherichia coli prevents wasting triggered by infections or physical damage to the intestine. During intest...

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Publicat a:Science
Autors principals: Palaferri Schieber, Alexandria M., Lee, Yujung Michelle, Chang, Max W., Leblanc, Mathias, Collins, Brett, Downes, Michael, Evans, Ronald M., Ayres, Janelle S.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732872/
https://ncbi.nlm.nih.gov/pubmed/26516283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac6468
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