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LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1

Cardiolipin (also known as PDL6) is an indispensable lipid required for mitochondrial respiration that is generated through de novo synthesis and remodeling. Here, the cardiolipin remodeling enzyme, acyl-CoA:lysocardiolipin-acyltransferase-1 (Alcat1; SwissProt ID, Q6UWP7) is destabilized in epitheli...

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Библиографические подробности
Опубликовано в: :J Cell Sci
Главные авторы: Zou, Chunbin, Synan, Matthew J., Li, Jin, Xiong, Sheng, Manni, Michelle L., Liu, Yuan, Chen, Bill B., Zhao, Yutong, Shiva, Sruti, Tyurina, Yulia Y., Jiang, Jianfei, Lee, Janet S., Das, Sudipta, Ray, Anuradha, Ray, Prabir, Kagan, Valerian E., Mallampalli, Rama K.
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists Ltd 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732295/
https://ncbi.nlm.nih.gov/pubmed/26604221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.176701
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