Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3

DEAD-box proteins utilize ATP to bind and remodel RNA and RNA-protein complexes. All DEAD-box proteins share a conserved core that consists of two RecA-like domains. The core is flanked by subfamily-specific extensions of idiosyncratic function. The Ded1/DDX3 subfamily of DEAD-box proteins is of par...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Floor, Stephen N., Condon, Kendall J., Sharma, Deepak, Jankowsky, Eckhard, Doudna, Jennifer A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732223/
https://ncbi.nlm.nih.gov/pubmed/26598523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.700625
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