Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels

Many cancer cells follow an aberrant metabolic program to maintain energy for rapid cell proliferation. Metabolic reprogramming often involves the upregulation of glutaminolysis to generate reducing equivalents for the electron transport chain and amino acids for protein synthesis. Critical enzymes...

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Bibliografski detalji
Izdano u:Redox Biol
Glavni autori: Smith, M. Ryan, Vayalil, Praveen K., Zhou, Fen, Benavides, Gloria A., Beggs, Reena R., Golzarian, Hafez, Nijampatnam, Bhavitavya, Oliver, Patsy G., Smith, Robin A.J., Murphy, Michael P., Velu, Sadanandan E., Landar, Aimee
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2016
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732023/
https://ncbi.nlm.nih.gov/pubmed/26774751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.01.002
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