Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels

Many cancer cells follow an aberrant metabolic program to maintain energy for rapid cell proliferation. Metabolic reprogramming often involves the upregulation of glutaminolysis to generate reducing equivalents for the electron transport chain and amino acids for protein synthesis. Critical enzymes...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Smith, M. Ryan, Vayalil, Praveen K., Zhou, Fen, Benavides, Gloria A., Beggs, Reena R., Golzarian, Hafez, Nijampatnam, Bhavitavya, Oliver, Patsy G., Smith, Robin A.J., Murphy, Michael P., Velu, Sadanandan E., Landar, Aimee
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732023/
https://ncbi.nlm.nih.gov/pubmed/26774751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.01.002
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