Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels

Many cancer cells follow an aberrant metabolic program to maintain energy for rapid cell proliferation. Metabolic reprogramming often involves the upregulation of glutaminolysis to generate reducing equivalents for the electron transport chain and amino acids for protein synthesis. Critical enzymes...

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Dades bibliogràfiques
Publicat a:Redox Biol
Autors principals: Smith, M. Ryan, Vayalil, Praveen K., Zhou, Fen, Benavides, Gloria A., Beggs, Reena R., Golzarian, Hafez, Nijampatnam, Bhavitavya, Oliver, Patsy G., Smith, Robin A.J., Murphy, Michael P., Velu, Sadanandan E., Landar, Aimee
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732023/
https://ncbi.nlm.nih.gov/pubmed/26774751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.01.002
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