SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice

Huntington’s disease (HD) is a neurodegenerative disorder for which there are no disease-modifying treatments. SIRT1 is a NAD(+)-dependent protein deacetylase that is implicated in maintaining neuronal health during development, differentiation and ageing. Previous studies suggested that the modulat...

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Publicat a:PLoS One
Autors principals: Tulino, Raffaella, Benjamin, Agnesska C., Jolinon, Nelly, Smith, Donna L., Chini, Eduardo N., Carnemolla, Alisia, Bates, Gillian P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731418/
https://ncbi.nlm.nih.gov/pubmed/26815359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145425
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