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SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo

Huntington's disease (HD) is a devastating neurodegenerative disorder for which there are no disease-modifying treatments. The molecular pathogenesis of HD is complex and many mechanisms and cellular processes have been proposed as potential sites of therapeutic intervention. However, prior to...

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Bibliografski detalji
Glavni autori: Bobrowska, Anna, Donmez, Gizem, Weiss, Andreas, Guarente, Leonard, Bates, Gillian
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325254/
https://ncbi.nlm.nih.gov/pubmed/22511966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034805
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