Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

Follicular lymphoma is an incurable B-cell malignancy(1) characterized by the t(14;18) and mutations in one or more components of the epigenome(2,3). Whilst frequent gene mutations in signaling pathways, including JAK-STAT, NOTCH and NF-κB, have also been defined(2–7), the spectrum of these mutation...

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Библиографические подробности
Опубликовано в: :Nat Genet
Главные авторы: Okosun, Jessica, Wolfson, Rachel L., Wang, Jun, Araf, Shamzah, Wilkins, Lucy, Castellano, Brian M., Escudero-Ibarz, Leire, Al Seraihi, Ahad Fahad, Richter, Julia, Bernhart, Stephan H., Efeyan, Alejo, Iqbal, Sameena, Matthews, Janet, Clear, Andrew, Guerra-Assunção, José Afonso, Bödör, Csaba, Quentmeier, Hilmar, Mansbridge, Christopher, Johnson, Peter, Davies, Andrew, Strefford, Jonathan C., Packham, Graham, Barrans, Sharon, Jack, Andrew, Du, Ming-Qing, Calaminici, Maria, Lister, T. Andrew, Auer, Rebecca, Montoto, Silvia, Gribben, John G., Siebert, Reiner, Chelala, Claude, Zoncu, Roberto, Sabatini, David M., Fitzgibbon, Jude
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731318/
https://ncbi.nlm.nih.gov/pubmed/26691987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3473
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