P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse

Phosphoinositide-3 kinase (PI3K) pathway activation contributes to mantle cell lymphoma (MCL) pathogenesis, but early-phase studies of the PI3K p110δ inhibitor GS-1101 have reported inferior responses in MCL compared with other non-Hodgkin lymphomas. Because the relative importance of the class IA P...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Iyengar, Sunil, Clear, Andrew, Bödör, Csaba, Maharaj, Lenushka, Lee, Abigail, Calaminici, Maria, Matthews, Janet, Iqbal, Sameena, Auer, Rebecca, Gribben, John, Joel, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606064/
https://ncbi.nlm.nih.gov/pubmed/23341541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-10-460832
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados