P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse

Phosphoinositide-3 kinase (PI3K) pathway activation contributes to mantle cell lymphoma (MCL) pathogenesis, but early-phase studies of the PI3K p110δ inhibitor GS-1101 have reported inferior responses in MCL compared with other non-Hodgkin lymphomas. Because the relative importance of the class IA P...

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Hlavní autoři: Iyengar, Sunil, Clear, Andrew, Bödör, Csaba, Maharaj, Lenushka, Lee, Abigail, Calaminici, Maria, Matthews, Janet, Iqbal, Sameena, Auer, Rebecca, Gribben, John, Joel, Simon
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606064/
https://ncbi.nlm.nih.gov/pubmed/23341541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-10-460832
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