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Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?

High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical studies have begun to challenge this view. We develop a very general framework for modeling and understanding resistance emergence based on principles from evolutionar...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: Day, Troy, Read, Andrew F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731197/
https://ncbi.nlm.nih.gov/pubmed/26820986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004689
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