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Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?
High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical studies have begun to challenge this view. We develop a very general framework for modeling and understanding resistance emergence based on principles from evolutionar...
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| Publié dans: | PLoS Comput Biol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4731197/ https://ncbi.nlm.nih.gov/pubmed/26820986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004689 |
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