TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors

Tumor cells frequently escape from CD8(+) T cell recognition by abrogating MHC-I antigen presentation. Deficiency in processing components, like the transporter associated with antigen processing (TAP), results in strongly decreased surface display of peptide/MHC-I complexes. We previously identifie...

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Publicat a:J Clin Invest
Autors principals: Doorduijn, Elien M., Sluijter, Marjolein, Querido, Bianca J., Oliveira, Cláudia C., Achour, Adnane, Ossendorp, Ferry, van der Burg, Sjoerd H., van Hall, Thorbald
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731191/
https://ncbi.nlm.nih.gov/pubmed/26784543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83671
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