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Chemical synthesis of erythropoietin glycoforms for insights into the relationship between glycosylation pattern and bioactivity
The role of sialyloligosaccharides on the surface of secreted glycoproteins is still unclear because of the difficulty in the preparation of sialylglycoproteins in a homogeneous form. We selected erythropoietin (EPO) as a target molecule and designed an efficient synthetic strategy for the chemical...
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| Publicado en: | Sci Adv |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Association for the Advancement of Science
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4730857/ https://ncbi.nlm.nih.gov/pubmed/26824070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500678 |
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