DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.
A number of DNA minor groove-binding ligands (MGBLs) are known to exhibit antitumor and antimicrobial activities. We show that DNA topoisomerase (Topo) I may be a pharmacological target of MGBLs. In the presence of calf thymus Topo I, MGBLs induced limited but highly specific single-strand DNA break...
Na minha lista:
| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47302/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7690143/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.17.8131 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|