17β-estradiol activates mTOR in chondrocytes by AKT-dependent and AKT-independent signaling pathways

To confirm whether 17β-estradiol (E2) activates mammalian target of rapamycin (mTOR) signaling pathway in chondrocytes and in what way activates mTOR. Human immortalized chondrocytes cell lines TC28a2 and C28/I2 were subjected to incubate with or without E2, LY294002 (the inhibitor of PI3K), rapamyc...

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Bibliografische gegevens
Gepubliceerd in:Int J Clin Exp Pathol
Hoofdauteurs: Tao, Yulei, Sun, Haibiao, Sun, Hongyan, Qiu, Xianxing, Xu, Changbo, Shi, Changxiu, Du, Jiahui
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: e-Century Publishing Corporation 2015
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730076/
https://ncbi.nlm.nih.gov/pubmed/26884863
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