Evaluation of Immunogenicity and Protective Efficacy Elicited by Mycobacterium bovis BCG Overexpressing Ag85A Protein against Mycobacterium tuberculosis Aerosol Infection

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is currently the only vaccine available for preventing tuberculosis (TB), however, BCG has varying success in preventing pulmonary TB. In this study, a recombinant BCG (rBCG::Ag85A) strain overexpressing the immunodominant Ag85A antigen was construc...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Xu, Zheng Zhong, Chen, Xiang, Hu, Ting, Meng, Chuang, Wang, Xiao Bo, Rao, Yan, Zhang, Xiao Ming, Yin, Yue Lan, Pan, Zhi Ming, Jiao, Xin An
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729882/
https://ncbi.nlm.nih.gov/pubmed/26858942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2016.00003
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