Evaluation of Immunogenicity and Protective Efficacy Elicited by Mycobacterium bovis BCG Overexpressing Ag85A Protein against Mycobacterium tuberculosis Aerosol Infection

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is currently the only vaccine available for preventing tuberculosis (TB), however, BCG has varying success in preventing pulmonary TB. In this study, a recombinant BCG (rBCG::Ag85A) strain overexpressing the immunodominant Ag85A antigen was construc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Infect Microbiol
Hauptverfasser: Xu, Zheng Zhong, Chen, Xiang, Hu, Ting, Meng, Chuang, Wang, Xiao Bo, Rao, Yan, Zhang, Xiao Ming, Yin, Yue Lan, Pan, Zhi Ming, Jiao, Xin An
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729882/
https://ncbi.nlm.nih.gov/pubmed/26858942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2016.00003
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