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Profilin Interaction with Actin Filament Barbed End Controls Dynamic Instability, Capping, Branching, and Motility

Cell motility and actin homeostasis depend on the control of polarized growth of actin filaments. Profilin, an abundant regulator of actin dynamics, supports filament assembly at barbed ends by binding G-actin. Here, we demonstrate how, by binding and destabilizing filament barbed ends at physiologi...

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Dettagli Bibliografici
Pubblicato in:Dev Cell
Autori principali: Pernier, Julien, Shekhar, Shashank, Jegou, Antoine, Guichard, Bérengère, Carlier, Marie-France
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729542/
https://ncbi.nlm.nih.gov/pubmed/26812019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.12.024
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