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Formin and capping protein together embrace the actin filament in a ménage à trois

Proteins targeting actin filament barbed ends play a pivotal role in motile processes. While formins enhance filament assembly, capping protein (CP) blocks polymerization. On their own, they both bind barbed ends with high affinity and very slow dissociation. Their barbed-end binding is thought to b...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Shekhar, Shashank, Kerleau, Mikael, Kühn, Sonja, Pernier, Julien, Romet-Lemonne, Guillaume, Jégou, Antoine, Carlier, Marie-France
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660058/
https://ncbi.nlm.nih.gov/pubmed/26564775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9730
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