Spire and Formin 2 Synergize and Antagonize in Regulating Actin Assembly in Meiosis by a Ping-Pong Mechanism

In mammalian oocytes, three actin binding proteins, Formin 2 (Fmn2), Spire, and profilin, synergistically organize a dynamic cytoplasmic actin meshwork that mediates translocation of the spindle toward the cortex and is required for successful fertilization. Here we characterize Fmn2 and elucidate t...

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Detalhes bibliográficos
Main Authors: Montaville, Pierre, Jégou, Antoine, Pernier, Julien, Compper, Christel, Guichard, Bérengère, Mogessie, Binyam, Schuh, Melina, Romet-Lemonne, Guillaume, Carlier, Marie-France
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934834/
https://ncbi.nlm.nih.gov/pubmed/24586110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001795
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