Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs

The mechanisms by which drugs induce pancreatitis are unknown. A definite cause of pancreatitis is due to the antiepileptic drug valproic acid (VPA). On the basis of three crucial observations—that VPA inhibits histone deacetylases (HDACs), HDACs mediate pancreas development, and aspects of pancreas...

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Dades bibliogràfiques
Publicat a:Am J Pathol
Autors principals: Eisses, John F., Criscimanna, Angela, Dionise, Zachary R., Orabi, Abrahim I., Javed, Tanveer A., Sarwar, Sheharyar, Jin, Shunqian, Zhou, Lili, Singh, Sucha, Poddar, Minakshi, Davis, Amy W., Tosun, Akif Burak, Ozolek, John A., Lowe, Mark E., Monga, Satdarshan P., Rohde, Gustavo K., Esni, Farzad, Husain, Sohail Z.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2015
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729237/
https://ncbi.nlm.nih.gov/pubmed/26476347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.08.006
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