Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs

The mechanisms by which drugs induce pancreatitis are unknown. A definite cause of pancreatitis is due to the antiepileptic drug valproic acid (VPA). On the basis of three crucial observations—that VPA inhibits histone deacetylases (HDACs), HDACs mediate pancreas development, and aspects of pancreas...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Eisses, John F., Criscimanna, Angela, Dionise, Zachary R., Orabi, Abrahim I., Javed, Tanveer A., Sarwar, Sheharyar, Jin, Shunqian, Zhou, Lili, Singh, Sucha, Poddar, Minakshi, Davis, Amy W., Tosun, Akif Burak, Ozolek, John A., Lowe, Mark E., Monga, Satdarshan P., Rohde, Gustavo K., Esni, Farzad, Husain, Sohail Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729237/
https://ncbi.nlm.nih.gov/pubmed/26476347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.08.006
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