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Population pharmacokinetics and optimization of the dosing regimen of digoxin in adult patients
BACKGROUND: This study aimed to evaluate the population pharmacokinetics of digoxin in Japanese patients and establish a dosage regimen based on the pharmacokinetic data. METHODS: We analyzed 287 serum digoxin samples from 192 individuals by using the nonlinear mixed effects model. We used simulatio...
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| Publicado en: | J Pharm Health Care Sci |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4728823/ https://ncbi.nlm.nih.gov/pubmed/26819736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40780-015-0023-6 |
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