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Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response

Antigen receptor diversity underpins adaptive immunity by providing the ground for clonal selection of lymphocytes with the appropriate antigen reactivity. Current models attribute T cell clonal selection during the immune response to T-cell receptor (TCR) affinity for either foreign or self peptide...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Merkenschlager, Julia, Ploquin, Mickaël J., Eksmond, Urszula, Andargachew, Rakieb, Thorborn, Georgina, Filby, Andrew, Pepper, Marion, Evavold, Brian, Kassiotis, George
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728444/
https://ncbi.nlm.nih.gov/pubmed/26728651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10281
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