Trimetazidine prevents macrophage‐mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1

BACKGROUND AND PURPOSE: Sepsis is a systemic inflammatory response accompanied by excessive production of inflammatory cytokines and cardiovascular dysfunction. Importantly, macrophage‐derived pro‐inflammatory agents play a key role in cardiovascular impairment in sepsis. Here we have investigated t...

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Publicat a:Br J Pharmacol
Autors principals: Chen, Jing, Lai, Jinsheng, Yang, Lei, Ruan, Guoran, Chaugai, Sandip, Ning, Qin, Chen, Chen, Wang, Dao Wen
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728416/
https://ncbi.nlm.nih.gov/pubmed/26566260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13386
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