A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice

BRCA1 is an important mediator of the DNA damage response, which promotes homologous recombination (HR) and antagonizes 53BP1-dependent non-homologous end joining in S/G2 phase. But how this is achieved remains unclear. Here, we report that the E3 ubiquitin ligase UHRF1 (Ubiquitin-like, with PHD and...

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Vydáno v:Nat Commun
Hlavní autoři: Zhang, Haoxing, Liu, Hailong, Chen, Yali, Yang, Xu, Wang, Panfei, Liu, Tongzheng, Deng, Min, Qin, Bo, Correia, Cristina, Lee, Seungbaek, Kim, Jungjin, Sparks, Melanie, Nair, Asha A., Evans, Debra L., Kalari, Krishna R., Zhang, Pumin, Wang, Liewei, You, Zhongsheng, Kaufmann, Scott H., Lou, Zhenkun, Pei, Huadong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728409/
https://ncbi.nlm.nih.gov/pubmed/26727879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10201
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