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Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase plays a major role in mitosis and emerging evidence indicates that PLK1 is also i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biol Open
Prif Awduron: O'Connor, Aisling, Maffini, Stefano, Rainey, Michael D., Kaczmarczyk, Agnieszka, Gaboriau, David, Musacchio, Andrea, Santocanale, Corrado
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Ltd 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728306/
https://ncbi.nlm.nih.gov/pubmed/26685311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.014969
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