A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

The spindle assembly checkpoint (SAC) monitors and promotes kinetochore–microtubule attachment during mitosis. Bub1 and BubR1, SAC components, originated from duplication of an ancestor gene. Subsequent sub-functionalization established subordination: Bub1, recruited first to kinetochores, promotes...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Overlack, Katharina, Primorac, Ivana, Vleugel, Mathijs, Krenn, Veronica, Maffini, Stefano, Hoffmann, Ingrid, Kops, Geert J P L, Musacchio, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337726/
https://ncbi.nlm.nih.gov/pubmed/25611342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05269
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