A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

The spindle assembly checkpoint (SAC) monitors and promotes kinetochore–microtubule attachment during mitosis. Bub1 and BubR1, SAC components, originated from duplication of an ancestor gene. Subsequent sub-functionalization established subordination: Bub1, recruited first to kinetochores, promotes...

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Publicado en:eLife
Autores principales: Overlack, Katharina, Primorac, Ivana, Vleugel, Mathijs, Krenn, Veronica, Maffini, Stefano, Hoffmann, Ingrid, Kops, Geert J P L, Musacchio, Andrea
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337726/
https://ncbi.nlm.nih.gov/pubmed/25611342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05269
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