Dual-therapy with α(v)β(3)-targeted Sn2 lipase-labile Fumagillin-prodrug Nanoparticles and Zoledronic Acid in the Vx2 Rabbit Tumor Model

Fumagillin, an unstable anti-angiogenesis mycotoxin, was synthesized into a stable lipase-labile prodrug and incorporated into integrin-targeted lipid-encapsulated nanoparticles (α(v)β(3)-Fum-PD NP). Dual anti-angiogenic therapy combining α(v)β(3)-Fum-PD NP with zoledronic acid (ZA), a long-acting o...

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Detalhes bibliográficos
Publicado no:Nanomedicine
Main Authors: Esser, Alison K., Schmieder, Anne H., Ross, Michael H., Xiang, Jingyu, Su, Xinming, Cui, Grace, Zhang, Huiying, Yang, Xiaoxia, Allen, John S., Williams, Todd, Wickline, Samuel A., Pan, Dipanjan, Lanza, Gregory M., Weilbaecher, Katherine N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727985/
https://ncbi.nlm.nih.gov/pubmed/26515754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2015.10.003
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