Antiangiogenic nanotherapy with lipase-labile Sn-2 fumagillin prodrug

BACKGROUND: The chemical instability of antiangiogenic fumagillin, combined with its poor retention during intravascular transit, requires an innovative solution for clinical translation. We hypothesized that an Sn-2 lipase-labile fumagillin prodrug in combination with a contact-facilitated drug del...

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Detalhes bibliográficos
Main Authors: Pan, Dipanjan, Sanyal, Nibedita, Schmieder, Anne H, Senpan, Angana, Kim, Benjamin, Yang, Xiaoxia, Hu, Grace, Allen, John S, Gross, Richard W, Wickline, Samuel A, Lanza, Gregory M
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498609/
https://ncbi.nlm.nih.gov/pubmed/22709347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.12.27
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