Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases

Small molecule inhibitors targeting the mitogen-activated protein kinase pathway (Braf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase) have had success in extending survival for patients with metastatic melanoma. Unfortunately, resistance may occur via cross-activation...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Vaidhyanathan, Shruthi, Wilken-Resman, Brynna, Ma, Daniel J., Parrish, Karen E., Mittapalli, Rajendar K., Carlson, Brett L., Sarkaria, Jann N., Elmquist, William F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2016
Schlagworte:
Metabolism, Transport, and Pharmacogenomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727156/
https://ncbi.nlm.nih.gov/pubmed/26604245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229393
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