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Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice

AIM: To investigate whether IDH1R132C mutant in combination with loss of p53 and activated Notch signaling promotes intrahepatic cholangiocarcinoma (ICC) development. METHODS: We applied hydrodynamic injection and sleeping beauty mediated somatic integration to induce loss of p53 (via shP53), activa...

詳細記述

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書誌詳細
出版年:World J Gastroenterol
主要な著者: Ding, Ning, Che, Li, Li, Xiao-Lei, Liu, Yan, Jiang, Li-Jie, Fan, Biao, Tao, Jun-Yan, Chen, Xin, Ji, Jia-Fu
フォーマット: Artigo
言語:Inglês
出版事項: Baishideng Publishing Group Inc 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726679/
https://ncbi.nlm.nih.gov/pubmed/26877611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v22.i6.2071
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