Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies

The development of carbohydrate-based antitumor vaccines is an attractive approach towards tumor prevention and treatment. Herein, we focused on the ganglioside GM2 tumor-associated carbohydrate antigen (TACA), which is overexpressed in a wide range of tumor cells. GM2 was synthesized chemically and...

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Veröffentlicht in:Chembiochem
Hauptverfasser: Yin, Zhaojun, Dulaney, Steven, McKay, Craig S., Baniel, Claire, Kaczanowska, Katarzyna, Ramadan, Sherif, Finn, M. G., Huang, Xuefei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726457/
https://ncbi.nlm.nih.gov/pubmed/26538065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500499
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