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The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels

Voltage-gated potassium (Kv) channels are essential for setting neuronal membrane excitability. Mutations in human Kv1.1 channels are linked to episodic ataxia type 1 (EA1). The EA1-associated mutation I262T was identified from a patient with atypical phenotypes. Although a previous report has chara...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Szu-Han, Fu, Ssu-Ju, Huang, Jing-Jia, Tang, Chih-Yung
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726062/
https://ncbi.nlm.nih.gov/pubmed/26778656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19378
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