c-Raf promotes angiogenesis during normal growth plate maturation

Extracellular phosphate plays a key role in growth plate maturation by inducing Erk1/2 (Mapk3/1) phosphorylation, leading to hypertrophic chondrocyte apoptosis. The Raf kinases induce Mek1/2 (Map2k1/2) and Erk1/2 phosphorylation; however, a role for Raf kinases in endochondral bone formation has not...

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Vydáno v:Development
Hlavní autoři: Liu, Eva S., Raimann, Adalbert, Chae, Byongsoo Timothy, Martins, Janaina S., Baccarini, Manuela, Demay, Marie B.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725343/
https://ncbi.nlm.nih.gov/pubmed/26657770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.127142
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