Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine

Development of an effective vaccine targeting tumor associated carbohydrate antigens (TACAs) is an appealing approach toward tumor immunotherapy. While much emphasis has been typically placed on generating high antibody titers against the immunizing antigen, the impact of immunogen design on the div...

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Udgivet i:ACS Chem Biol
Main Authors: Yin, Zhaojun, Chowdhury, Sudipa, McKay, Craig, Baniel, Claire, Wright, W. Shea, Bentley, Philip, Kaczanowska, Katarzyna, Gildersleeve, Jeffrey C., Finn, M.G., BenMohamed, Lbachir, Huang, Xuefei
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725323/
https://ncbi.nlm.nih.gov/pubmed/26262839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00406
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