Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties

OBJECTIVE—: Apolipoprotein A-I (apoA-I) has been shown to possess several atheroprotective functions, including inhibition of inflammation. Protease-secreting activated mast cells reside in human atherosclerotic lesions. Here we investigated the effects of the neutral proteases released by activated...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Nguyen, Su Duy, Maaninka, Katariina, Lappalainen, Jani, Nurmi, Katariina, Metso, Jari, Öörni, Katariina, Navab, Mohamad, Fogelman, Alan M., Jauhiainen, Matti, Lee-Rueckert, Miriam, Kovanen, Petri T.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
Assuntos:
Basic Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725095/
https://ncbi.nlm.nih.gov/pubmed/26681753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306827
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