Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr(192) and compromises its cardioprotective activity

ApoA-I, the main structural and functional protein of HDL particles, is cardioprotective, but also highly sensitive to proteolytic cleavage. Here, we investigated the effect of cardiac mast cell activation and ensuing chymase secretion on apoA-I degradation using isolated rat hearts in the Langendor...

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Detaylı Bibliyografya
Yayımlandı:J Lipid Res
Asıl Yazarlar: Kareinen, Ilona, Baumann, Marc, Nguyen, Su Duy, Maaninka, Katariina, Anisimov, Andrey, Tozuka, Minoru, Jauhiainen, Matti, Lee-Rueckert, Miriam, Kovanen, Petri T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Biochemistry and Molecular Biology 2018
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983404/
https://ncbi.nlm.nih.gov/pubmed/29581158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M077503
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