Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

Copper is a transition metal that plays critical roles in many life processes. Controlling the cellular concentration and trafficking of copper offers a route to disrupt these processes. Here we report small molecules that inhibit the human copper-trafficking proteins Atox1 and CCS, and so provide a...

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Publicado no:Nat Chem
Main Authors: Wang, Jing, Luo, Cheng, Shan, Changliang, You, Qiancheng, Lu, Junyan, Elf, Shannon, Zhou, Yu, Wen, Yi, Vinkenborg, Jan L., Fan, Jun, Kang, Heebum, Lin, Ruiting, Han, Dali, Xie, Yuxin, Karpus, Jason, Chen, Shijie, Ouyang, Shisheng, Luan, Chihao, Zhang, Naixia, Ding, Hong, Merkx, Maarten, Liu, Hong, Chen, Jing, Jiang, Hualiang, He, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725056/
https://ncbi.nlm.nih.gov/pubmed/26587712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2381
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