Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site

Helicobacter pylori is associated with inflammatory diseases and can cause gastric cancer and mucosa-associated lymphoma. One of the bacterium’s key proteins is high temperature requirement A (HpHtrA) protein, an extracellular serine protease that cleaves E-cadherin of gastric epithelial cells, whic...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Perna, Anna Maria, Reisen, Felix, Schmidt, Thomas P., Geppert, Tim, Pillong, Max, Weisel, Martin, Hoy, Benjamin, Simister, Philip C., Feller, Stephan M., Wessler, Silja, Schneider, Gisbert
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724879/
https://ncbi.nlm.nih.gov/pubmed/26819700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4SC01443J
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